SYSON was established in 2013 by curator Jennie Syson as an independent contemporary art gallery in Nottingham. The gallery worked with a range of artists in the city and beyond on a number of ambitious exhibitions, editions, art fairs and commissions. In the gallery's first year, Jennie Syson was nominated for the Paul Hamlyn Breakthrough Award. 

 

The gallery programme included talks and events, artists' book and zine fairs, and regular Reading Room sessions where texts pertaining to contemporary art and critical theory were discussed in an informal and relaxed setting. Each year, the gallery the SYSON prize at Nottingham Castle Museums annual open exhibition, which resulted in an exhibition and artists' development for recipients.

Syson Gallery closed in April 2018.